Rickettsia MIF substrate slides are available for all or most of the officially validated species, 16 of which are currently recognized as human pathogens. These slides feature purified Rickettsia elementary bodies within a contrasting background matrix, with up to 6 antigens per slide well.
Several of the 2-3 antigen formats are stocked for general screening purposes (see image below). Other multi-antigen substrate slides are prepared on a custom basis with combinations of Rickettsia with other particulate antigens (Anaplasma, Ehrlichia, Coxiella, Bartonella, etc). This affords the opportunity for testing facilities to configure screening slides with broader or more specific utility.
Note: Due to the presence of an immunodominant lipopolysaccharide (LPS) antigen on native spotted fever and typhus group Rickettsia, the occurrance of false-positives due to this antigen compromises the value of both IFA and MIF protocols for IgM testing. We strongly recommend ELISA protocols using our Omp antigens (LPS-free) for IgM testing.